Novel therapeutic strategies targeting HIV integrase
نویسندگان
چکیده
منابع مشابه
Novel therapeutic strategies targeting HIV integrase
Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After concerted efforts, the first viable integrase inhibitors were developed in the early 2000s, ul...
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ژورنال
عنوان ژورنال: BMC Medicine
سال: 2012
ISSN: 1741-7015
DOI: 10.1186/1741-7015-10-34